Nanoscale biophysical approaches to the cure of disease are rapidly becoming a standard part of the repertoire of medical research laboratories. We have instituted a new interdisciplinary program of research in this area, headed by Dr. David Callaway. This Laboratory is concerned with the development and application of techniques for the design of molecular medicine. Protein chemistry techniques as well as molecular biological experimental work are guided by theoretical methodology. A particular focus of the laboratory is Alzheimer's disease, and related (prion-like) amyloidoses.

Trained as a theoretical physicist, Dr. Callaway has formulated accurate and practical mathematical models of phenomena ranging from elementary particles to superconductors. He has since produced a model of heme proteins that allowed the folding dynamics of myoglobin to be explored computationally, and a model of the hydrophobic effect based upon a mathematical formalism invented for the study of black holes. Presently he works on determining protein internal dynamics by neutron spin-echo spectroscopy.

Summary of Alzheimer's program HERE!

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A recent publication HERE! Controlling amyloid beta-peptide fibril formation with protease stable ligands. J. Biol. Chem. 1997 272 (19): 12601-12605; 272 (28): 17894.

Another recent publication HERE! (PDF format) A molecular model of Alzheimer amyloid beta-peptide fibril formation. J. Biol. Chem. 1999 274, 12619-12625.

Another recent publication HERE! (PDF format) Dynamic regimes and correlated structural dynamics in protein folding: A quasielastic neutron scattering study. Z. Bu, J. Cook, D.J.E. Callaway. J. Mol. Biol. (2001) 312, 865-873.

Another recent publication HERE! (PDF format) New class of beta-amyloid aggregation inhibitors: Implications for the mechanism of pathogenesis in Alzheimer's disease. H. A. Lashuel, D. M. Hartley, D. Balakhaneh, A. Aggarwal, S. Teichberg, D.J.E. Callaway. J. Biol. Chem., (2002) 277,42881-42890.

Another recent publication HERE! (PDF format) Assembling amyloid fibrils from designed structures containing a significant Alzheimer beta-peptide fragment. L.O. Tjernberg, A. Tjernberg, N. Bark, Y. Shi, B. P. Ruzsicska, Z. Bu, J. Thyberg, D.J.E. Callaway. Biochem. J. (2002) 366, 343-351.

Another recent publication HERE! (PDF format) Structure-specific DNA induced conformational changes in Taq polymerase revealed by small angle neutron scattering. Derek L. Ho, W. Malcolm Byrnes, W. P. Ma, Yuan Shi, D.J.E. Callaway (co-corresponding), Zimei Bu. J. Biol. Chem., 2004 Sep 10;279(37):39146-54.

Another recent publication HERE! (PDF format) Bu Z, Biehl R, Monkenbusch M, Richter D, D.J.E. Callaway, Coupled protein domain motion in Taq polymerase revealed by neutron spin-echo spectroscopy. Proc Natl Acad Sci USA 2005 Dec 6;102(49):17646-17651.

Another recent publication HERE! (PDF format) Shi Y, Stouten PF, Pillalamarri N, Barile L, Rosal RV, Teichberg S, Bu Z, D.J.E. Callaway, Quantitative determination of the topological propensities of amyloidogenic peptides. Biophys Chem. 120 (2006), 55-61.

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Another recent publication HERE! (PDF format) Li J, Dai Z, Jana D, Callaway DJ, Bu Z. Ezrin controls the macromolecular complexes formed between an adapter protein Na+/H+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2005 Nov 11;280(45):37634-43.

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Theoretical physics publication HERE! (PDF format) Triviality pursuit: Can elementary scalar particles exist? D.J.E. Callaway, Phys. Reports 167 (1988), 241.

Theoretical physics publication HERE! (PDF format) On the remarkable structure of the superconducting intermediate state. D.J.E. Callaway, Nucl. Phys. B344 [FS] (1990) 627.

Theoretical physics publication HERE! (PDF format) Surface tension, hydrophobicity, and black holes: The entropic connection. D.J.E. Callaway, Phys. Rev. E53 (1996), 3738.

Theoretical physics publication HERE! (PDF format) Random matrices, fractional statistics, and the quantum Hall effect. D.J.E. Callaway, Phys. Rev. B43 (1991) 8641.

Theoretical physics publication HERE! (PDF format) Microcanonical ensemble formulation of lattice gauge theory. D.J.E. Callaway and A. Rahman, Phys. Rev. Lett. 49 (1982), 613.

Theoretical physics publication HERE! (PDF format) Non-triviality of gauge theories with elementary scalars and upper bounds on Higgs masses. D.J.E. Callaway, Nucl. Phys. B233 (1984), 189.

Theoretical physics publication HERE! (PDF format) Determination of critical points and flow diagrams by Monte Carlo renormalization group methods. D.J.E. Callaway and R. Petronzio, Phys. Lett. 139B (1984), 189.

Theoretical physics publication HERE! (PDF format) Effective potential of lattice phi^4 theory. D.J.E. Callaway and D.J. Maloof, Phys. Rev. D27 (1983), 406.

Theoretical physics publication HERE! (PDF format) Abelian Higgs model: A Monte Carlo study. D.J.E. Callaway and L.J. Carson, Phys. Rev. D25 (1982), 531.

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