Biological NanoPhysics

David J. E. Callaway, PhD
Professor and Laboratory Director
david dot callaway at nyu dot edu

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"There's plenty of room at the bottom: An invitation to enter a new field of physics."
−Richard Feynman−

★David J. E. Callaway★ (大卫·凯乐威) is a biological nanophysicist in the New York University School of Medicine. He is Professor and Laboratory Director. Dr Callaway has worked extensively in the field of Alzheimer's disease, specifically in understanding and controlling amyloid formation. His Alzheimer's program has developed and patented several potent new therapeutics for Alzheimer's disease, based upon apomorphine, which are discussed here. Dr Callaway initiated the study of protein domain dynamics by neutron spin echo spectroscopy, allowing the direct observation of protein nanomachinery in motion. Protein dynamics underlies the physics of cancer and other phenomena (like long-range allostery) essential for addressing human disease. It is also a cornerstone of synthetic biology.

Earlier work of his involved the invention (with Aneesur Rahman ) of the microcanonical ensemble approach to lattice gauge theory. This introduction of molecular dynamics methods significantly increased computational efficiency in the numerical simulation of quantum field theories. Other work showed that quantum triviality provided new constraints on the Higgs boson, such as a bounded or calculable Higgs mass. Professor Callaway later published a well-cited monograph on the subject. He has also shown a direct connection between black hole entropy and liquid surface tension. He also reformulated the Laughlin model of the fractional statistics quantum Hall effect using random matrix theory, affording a connection to geometric models of string theory, and showed that the superconducting intermediate state allowed a direct view of a quantum phase space.

In his ★copious★ free time, he sails the world and climbs its mountains. ( Mount Everest can be seen in the background).

Look at our lab click HERE!

LOOK at my research on ResearchGate, research on Academia●edu, research in high energy, nuclear, condensed matter and computational physics, research in biological nanophysics, research on Google Scholar, research on Mendeley, research on Scopus, profile on LinkedIn, profile on Wikipedia, and my profile on Google+.

A first look at nanoscale protein dynamics HERE!

Protein nanomachines are far more complex than any molecular machines that have yet been artificially constructed.
Their skillful utilization likely represents the future of medicine.
Our work clears significant hurdles to the use of this very important tool.
LOOK at our lab CLICK HERE!
SEE our Alzheimer's program HERE ....with my MILLION DOLLAR BABY!

Some climbing pix:

What I looked like (3 weeks without a bath) after climbing McKinley/Denali (Alaska) and HERE. Here I am at the summit And here I am halfway up, at Genet Basin. And here I am climbing the headwall above it, and And here I am finally coming home!

WIth Stuart McGuinness at Kilimanjaro summit (Tanzania/Kenya, Africa) HERE and HERE. Crossing into the arctic circle on Baffin Island ( Pangnirtung fjord, Nunavut) with Iain Nicholl and Stuart HERE and HERE.

Been there, done THAT( Aiguille de Rochefort, Alps) and THAT (north face, Tour Ronde, Chamonix, France) and THAT ( Aconcagua, Argentina/Chile). HERE I am at the summit. And HERE I am halfway up. At the summit of the Matterhorn (Switzerland/Italy) HERE. At the summit of the Eiger (Switzerland) HERE. And then there is THAT ( Mt Cook, New Zealand).

At Everest Base Camp with Brian Blessed and Pasang Sherpa

Sometimes, for relaxation, I go rock climbing like HERE in the Gunks. ( This is called Belly Roll). Some assorted Alpine climbs HERE and HERE and HERE. The Vallee Blanche, ( Mont Blanc , Chamonix, France) moments before I skied it. Going whitewatering after shark diving on the Great Barrier Reef. At the Khyber Pass (Afghanistan/Pakistan) HERE and HERE. Eating a soggy breakfast after a rainy night on Baffin Island. Danger! do not approach! Gathering intrepidness before another Baffin stream crossing HERE. Behind is Mt Thor, a 4101 foot granite cliff with a 105 degree overhang, making it the Earth's greatest purely vertical drop. An interesting climb. Climbing Everest with Brian Blessed and Pasang Sherpa shown HERE. Me at Everest base (Nepal) HERE and HERE.

Returning from another Himalayan expedition HERE. ( Lukla photo by my late friend Ginette Harrison.) Photo HERE of avalanche above Camp 1 on Broad Peak (Pakistan) -- A good thing I was slow on the way down! Making basecamp for Broad Peak on the Concordia Glacier is shown HERE. At the summit of Mt Cook (New Zealand) HERE and HERE and my friend Arthur Collins there (photo by me!) HERE. Fluid balance is essential at high altitude. HERE I demonstrate how to do it in Dingboche, Nepal. Climbing the Khumbu icefall on Everest HERE and HERE. At K2 Base Camp HERE. Note the neat Chamonix bag! At the summit of Mount Kosciuszko, the highest point of Australia HERE and HERE. Setting out to climb Broad Peak (Pakistan) with Mark Vallance (photo HERE). Our porter team in Pakistan HERE. Climbing the Dalle de l'Amone (aka the Amone slab) near Martigny Switzerland. Photo by my late friend Roger Payne. A newspaper interview from a few years ago.

Eco Challenge

See my brief TV career ( Eco Challenge , the event that started reality TV!) HERE, and HERE, and HERE, and HERE with Mark Burnett, and author time HERE. Sometimes I wear very nice clothes like HERE but mostly I am in my shambolic redoubt (i.e.,office) HERE unless I am giving a commencement address at Rockefeller like HERE or riding my horse through Brooklyn. Our lab meetings are somewhat unusual.

Me as a fresh PhD in Seattle HERE
My Erdos number is three, ( John R. Klauder, Jonathan Schaer, Paul Erdos)
as is my Einstein number ( John R. Klauder, Valentine Bargmann, Albert Einstein)
An article I wrote during my four years reporting for a great newspaper.
A good link for people who do not appreciate Biological Physics.
Typical med school salaries, long ago, when profs were POOR!.
Meet Shredder. Turbulence. Airmets.

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The Callaway Family Association. The KINGDOM of CALLAWAY. The Callaway Network. Callaway Golf. Callaway Gardens . Join the CALLAWAY CLUB!

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