David J. E. Callaway, PhD
Professor and Laboratory Director

Looking for a job? Want to get a PhD? Want a summer internship?

Apply HERE!

REAL Nanosecond Protein Dynamics! HERE NOW we can watch protein nanomachines MOVE

with neutron spin-echo spectroscopy!

Read all about it HERE!

Interdisciplinary nanoscale biophysical approaches to the cure of disease were once thought revolutionary, but are now rapidly becoming a standard part of the repertoire. We have instituted a new multidisciplinary program of research in this area, headed by Professor David Callaway. A recent focus of the laboratory is Alzheimer's disease, and related (prion-like) amyloidoses.

Trained as a theoretical physicist, Dr. Callaway has published research on topics ranging from elementary particles and superconductors to protein dynamics and structure-based drug design. Presently he works on probing protein internal dynamics by neutron spin-echo spectroscopy and other techniques, providing a novel way to observe protein nanomachines in motion.

Summary of Alzheimer's program HERE! ....along with my million dollar baby.

A recent publication HERE! Controlling amyloid beta-peptide fibril formation with protease stable ligands. J. Biol. Chem. 1997 272 (19): 12601-12605; 272 (28): 17894.

Another recent publication HERE! (PDF format) A molecular model of Alzheimer amyloid beta-peptide fibril formation. J. Biol. Chem. 1999 274, 12619-12625.

Another recent publication HERE! (PDF format) Dynamic regimes and correlated structural dynamics in protein folding: A quasielastic neutron scattering study. Z. Bu, J. Cook, D.J.E. Callaway. J. Mol. Biol. (2001) 312, 865-873.

Another recent publication HERE! (PDF format) New class of beta-amyloid aggregation inhibitors: Implications for the mechanism of pathogenesis in Alzheimer's disease. H. A. Lashuel, D. M. Hartley, D. Balakhaneh, A. Aggarwal, S. Teichberg, D.J.E. Callaway. J. Biol. Chem., (2002) 277,42881-42890.

Another recent publication HERE! (PDF format) Assembling amyloid fibrils from designed structures containing a significant Alzheimer beta-peptide fragment. L.O. Tjernberg, A. Tjernberg, N. Bark, Y. Shi, B. P. Ruzsicska, Z. Bu, J. Thyberg, D.J.E. Callaway. Biochem. J. (2002) 366, 343-351.

Another recent publication HERE! (PDF format) Structure-specific DNA induced conformational changes in Taq polymerase revealed by small angle neutron scattering. Derek L. Ho, W. Malcolm Byrnes, W. P. Ma, Yuan Shi, D.J.E. Callaway (co-corresponding), Zimei Bu. J. Biol. Chem., 2004 Sep 10;279(37):39146-54.

Another recent publication HERE! (PDF format) Bu Z, Biehl R, Monkenbusch M, Richter D, D.J.E. Callaway, Coupled protein domain motion in Taq polymerase revealed by neutron spin-echo spectroscopy. Proc Natl Acad Sci USA 2005 Dec 6;102(49):17646-17651.

Another recent publication HERE! (PDF format) D.J.E. Callaway, Solvent-induced organization: a physical model of folding myoglobin. Proteins. 1994 Oct;20(2):124-38. cond-mat 9406071 here and here

Another recent publication HERE! (PDF format) Shi Y, Stouten PF, Pillalamarri N, Barile L, Rosal RV, Teichberg S, Bu Z, D.J.E. Callaway, Quantitative determination of the topological propensities of amyloidogenic peptides. Biophys Chem. 120 (2006), 55-61.

Another recent publication HERE! (PDF format) Li J, Dai Z, Jana D, Callaway DJ, Bu Z. Ezrin controls the macromolecular complexes formed between an adapter protein Na+/H+ exchanger regulatory factor and the cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2005 Nov 11;280(45):37634-43.

Another recent publication HERE! (PDF format) Bu Z, Shi Y, D.J.E. Callaway, {co-corresponding}, and Tycko R. Molecular alignments within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J. 2007 92: p. 594-602.

Another recent publication HERE! (PDF format) Li J, Poulikakos PI, Dai Z, Testa JR, Callaway DJ, Bu Z. Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly. J Biol Chem. 2007 Sep 14;282(37):27086-99

Theoretical physics publication HERE! (PDF format) Triviality pursuit: Can elementary scalar particles exist? D.J.E. Callaway, Phys. Reports 167 (1988), 241.

Theoretical physics publication HERE! (PDF format) On the remarkable structure of the superconducting intermediate state. D.J.E. Callaway, Nucl. Phys. B344 [FS] (1990) 627.

Theoretical physics publication HERE! (PDF format) Langevin simulations in Minkowski space. D.J.E. Callaway, F. Cooper, J. R. Klauder, H. Rose. Nucl.Phys.B262:19,1985

Theoretical physics publication HERE! (PDF format) Surface tension, hydrophobicity, and black holes: The entropic connection. D.J.E. Callaway, Phys. Rev. E53 (1996), 3738.

Theoretical physics publication HERE! (PDF format) Random matrices, fractional statistics, and the quantum Hall effect. D.J.E. Callaway, Phys. Rev. B43 (1991) 8641.

Theoretical physics publication HERE! (PDF format) Microcanonical ensemble formulation of lattice gauge theory. D.J.E. Callaway and A. Rahman, Phys. Rev. Lett. 49 (1982), 613.

Theoretical physics publication HERE! (PDF format) Non-triviality of gauge theories with elementary scalars and upper bounds on Higgs masses. D.J.E. Callaway, Nucl. Phys. B233 (1984), 189.

Theoretical physics publication HERE! (PDF format) Determination of critical points and flow diagrams by Monte Carlo renormalization group methods. D.J.E. Callaway and R. Petronzio, Phys. Lett. 139B (1984), 189.

Theoretical physics publication HERE! (PDF format) Effective potential of lattice phi^4 theory. D.J.E. Callaway and D.J. Maloof, Phys. Rev. D27 (1983), 406.

Theoretical physics publication HERE! (PDF format) Abelian Higgs model: A Monte Carlo study. D.J.E. Callaway and L.J. Carson, Phys. Rev. D25 (1982), 531.

Looking for a job? Interested in studying Alzheimer's disease? Want to get a PhD? Want a summer internship? Apply HERE!

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