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NOW
we can watch protein nanomachines
MOVE
with
neutron spin-echo spectroscopy!
Read all about it
HERE!
Interdisciplinary nanoscale biophysical approaches to the cure of disease
were once thought revolutionary, but
are now rapidly becoming a standard part of the
repertoire. We have
instituted a new multidisciplinary program of research in this area, headed by
Professor David Callaway.
A recent focus of the laboratory is Alzheimer's disease, and
related (prion-like) amyloidoses.
Trained as a theoretical physicist, Dr. Callaway has published research on
topics ranging from elementary particles and superconductors
to protein dynamics and structure-based drug design.
Presently he works on probing protein internal dynamics by neutron spin-echo
spectroscopy and other techniques, providing a novel way to observe
protein nanomachines in motion.
Summary of Alzheimer's program
....along with my
million dollar
baby.
A recent publication
Controlling amyloid beta-peptide fibril formation
with protease stable ligands.
J. Biol. Chem.
1997 272 (19): 12601-12605;
272 (28): 17894.
Another recent publication
(PDF format)
A molecular model of Alzheimer amyloid beta-peptide
fibril formation. J. Biol. Chem. 1999 274, 12619-12625.
Another recent publication
(PDF format)
Dynamic regimes and correlated structural dynamics
in protein folding: A quasielastic neutron scattering
study. Z. Bu,
J. Cook,
D.J.E. Callaway.
J. Mol. Biol. (2001) 312, 865-873.
Another recent publication
(PDF format)
New class of beta-amyloid aggregation inhibitors:
Implications for the mechanism of pathogenesis in Alzheimer's
disease.
H. A. Lashuel,
D. M. Hartley,
D. Balakhaneh,
A. Aggarwal,
S. Teichberg,
D.J.E. Callaway.
J. Biol. Chem., (2002) 277,42881-42890.
Another recent publication
(PDF format)
Assembling amyloid fibrils from designed structures
containing a significant Alzheimer beta-peptide fragment.
L.O. Tjernberg,
A. Tjernberg,
N. Bark,
Y. Shi,
B. P. Ruzsicska,
Z. Bu,
J. Thyberg,
D.J.E. Callaway.
Biochem. J. (2002) 366, 343-351.
Another recent publication
(PDF format)
Structure-specific DNA induced conformational
changes in Taq polymerase revealed
by small angle neutron scattering.
Derek L. Ho,
W. Malcolm Byrnes,
W. P. Ma,
Yuan Shi,
D.J.E. Callaway (co-corresponding),
Zimei Bu.
J. Biol. Chem., 2004 Sep 10;279(37):39146-54.
Another recent publication
(PDF format)
Bu Z, Biehl R,
Monkenbusch M, Richter D,
D.J.E. Callaway,
Coupled protein domain motion in
Taq polymerase revealed by
neutron spin-echo spectroscopy.
Proc Natl Acad Sci USA
2005 Dec 6;102(49):17646-17651.
Another recent publication
(PDF format)
D.J.E. Callaway,
Solvent-induced organization: a physical model of folding myoglobin.
Proteins. 1994 Oct;20(2):124-38.
cond-mat 9406071 here
and
here
Another recent publication
(PDF format)
Shi Y, Stouten PF,
Pillalamarri N, Barile L,
Rosal RV, Teichberg S, Bu Z,
D.J.E. Callaway,
Quantitative determination
of the topological propensities
of amyloidogenic peptides.
Biophys Chem. 120 (2006), 55-61.
Another recent publication
(PDF format)
Li J, Dai Z, Jana D, Callaway DJ, Bu Z.
Ezrin controls the macromolecular complexes formed
between an adapter protein Na+/H+ exchanger regulatory factor
and the cystic fibrosis transmembrane conductance regulator.
J Biol Chem. 2005 Nov 11;280(45):37634-43.
Another recent publication
(PDF format)
Bu Z, Shi Y,
D.J.E. Callaway, {co-corresponding},
and Tycko R.
Molecular alignments within
beta-sheets in Abeta(14-23) fibrils:
solid-state NMR experiments and theoretical predictions.
Biophys J. 2007 92: p. 594-602.
Another recent publication
(PDF format)
Li J, Poulikakos PI, Dai Z, Testa JR, Callaway DJ, Bu Z.
Protein kinase C phosphorylation disrupts Na+/H+ exchanger regulatory factor 1 autoinhibition and promotes cystic fibrosis transmembrane conductance regulator macromolecular assembly.
J Biol Chem. 2007 Sep 14;282(37):27086-99
Theoretical physics publication
(PDF format)
Triviality pursuit: Can elementary scalar particles
exist? D.J.E. Callaway, Phys. Reports 167
(1988), 241.
Theoretical physics publication
(PDF format)
On the remarkable structure of the superconducting
intermediate state. D.J.E. Callaway, Nucl. Phys.
B344 [FS] (1990) 627.
Theoretical physics publication
(PDF format)
Langevin simulations in Minkowski space.
D.J.E. Callaway, F. Cooper, J. R. Klauder, H. Rose.
Nucl.Phys.B262:19,1985
Theoretical physics publication
(PDF format)
Surface tension, hydrophobicity, and black holes:
The entropic connection. D.J.E. Callaway,
Phys. Rev. E53 (1996), 3738.
Theoretical physics publication
(PDF format)
Random matrices, fractional statistics, and the
quantum Hall effect. D.J.E. Callaway, Phys. Rev.
B43 (1991) 8641.
Theoretical physics publication
(PDF format)
Microcanonical ensemble formulation of lattice gauge
theory. D.J.E. Callaway and A. Rahman, Phys. Rev. Lett.
49 (1982), 613.
Theoretical physics publication
(PDF format)
Non-triviality of gauge theories with elementary
scalars and upper bounds on Higgs masses. D.J.E. Callaway,
Nucl. Phys. B233 (1984), 189.
Theoretical physics publication
(PDF format)
Is the standard model Higgs mass predictable?D.J.E.
Callaway and R. Petronzio,
Nuclear Physics B, Volume 292, p. 497-526 (1987).
Theoretical physics publication
(PDF format)
Determination of critical points and flow diagrams
by Monte Carlo renormalization group methods. D.J.E.
Callaway and R. Petronzio, Phys. Lett. 139B
(1984), 189.
Theoretical physics publication
(PDF format)
Effective potential of lattice phi^4 theory.
D.J.E. Callaway and D.J. Maloof, Phys. Rev. D27
(1983), 406.
Theoretical physics publication
(PDF format)
Abelian Higgs model: A Monte Carlo study. D.J.E.
Callaway and L.J. Carson, Phys. Rev. D25 (1982), 531.
Looking for a job?
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