Research on Alzheimer's Disease

David J. E. Callaway, PhD
Professor and Laboratory Director

Learn about the lab HERE! and HERE!

Looking for a job? Interested in trying to cure Alzheimer's disease? Want to get a PhD? Want a summer internship? Apply HERE!

Potential therapeutics for Alzheimer's disease (PDF format)

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The polymerization of the amyloid beta-peptide into protease-resistant fibrils is a significant step in the pathogenesis of Alzheimer's disease. Compounds capable of interfering with the polymerization process thus may lead to potent therapeutics. In order to design such compounds, a detailed understanding of the polymerization process at the molecular level is essential. Conventional experimental techniques alone have lacked the precision to yield this detail. Accordingly, we employ a combination of biological, chemical, and physical techniques to understand and combat fibril formation.

Small-angle X-ray scattering (SAXS) with my MILLION DOLLAR BABY:

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A recent publication HERE! Controlling amyloid beta-peptide fibril formation with protease stable ligands. J. Biol. Chem. 1997 272 (19): 12601-12605; 272 (28): 17894.

Another recent publication HERE!
(PDF format) A molecular model of Alzheimer amyloid beta-peptide fibril formation. J. Biol. Chem. 1999 274, 12619-12625.

Another recent publication HERE! (PDF format) New class of beta-amyloid aggregation inhibitors: Implications for the mechanism of pathogenesis in Alzheimer's disease. H. A. Lashuel, D. M. Hartley, D. Balakhaneh, A. Aggarwal, S. Teichberg, D.J.E. Callaway. J. Biol. Chem., (2002) 277,42881-42890.

Another recent publication HERE! (PDF format)
Assembling amyloid fibrils from designed structures containing a significant Alzheimer beta-peptide fragment. L.O. Tjernberg, A. Tjernberg, N. Bark, Y. Shi, B. P. Ruzsicska, Z. Bu, J. Thyberg, D.J.E. Callaway. Biochem. J. (2002) 366, 343-351.

Another recent publication HERE! (PDF format) Shi Y, Stouten PF, Pillalamarri N, Barile L, Rosal RV, Teichberg S, Bu Z, D.J.E. Callaway, Quantitative determination of the topological propensities of amyloidogenic peptides. Biophys Chem. 120 (2006), 55-61.

Another recent publication HERE! (PDF format) Bu Z, Shi Y, D.J.E. Callaway, {co-corresponding}, and Tycko R. Molecular alignments within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions. Biophys J. 2007 92: p. 594-602.

Learn about the lab HERE!

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